You should not take dextromethorphan with combination products that also contain dextromethorphan. To learn more, see “Overdose” in the “Dextromethorphan dosage” section above. Here’s a list of some of the mild side effects dextromethorphan can cause. To learn about other mild side effects, talk with your doctor or pharmacist. Or read the drug’s labeling information for the capsules and the suspension.
Dextromethorphan can cause drowsiness, but this side effect isn’t common. Taking a higher dose of dextromethorphan may increase the risk of drowsiness. Talk with your doctor or pharmacist if you have questions or concerns about the dosage of dextromethorphan that is safe for you. For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms.
They may suggest a treatment to manage your symptoms and can determine whether you should keep taking dextromethorphan. Like most drugs, dextromethorphan may cause mild to serious side effects. This section describes some of the more common side effects dextromethorphan may cause. Talking to your teen about the risks of substance misuse can help them avoid behaviors and situations that could dextromethorphan cause drowsiness be harmful. If you think your child may be using dextromethorphan or other substances recreationally, talk to a healthcare provider immediately. If you overdose on Dextromethorphan, seek emergency medical attention.
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The most important adverse effects of acute quinidine overdose are ventricular arrhythmias and hypotension. Other signs and symptoms of overdose may include vomiting, diarrhea, tinnitus, high-frequency hearing loss, vertigo, blurred vision, diplopia, photophobia, headache, confusion, and delirium. When dextromethorphan/quinidine was orally administered (0/0, 5/50, 15/50, 25/50 mg/kg) to male and female rats on postnatal day (PND) 7, the highest dose resulted in neuronal death in brain (thalamus and medulla oblongata). PND 7 in rat corresponds to the third trimester of gestation through the first several months of life but may extend to approximately three years of age in humans. As with any other CNS drug, caution should be used when dextromethorphan hydrobromide and quinidine sulfate is taken in combination with other centrally acting drugs and alcohol.
It is part of the morphinan class of medications with sedative, dissociative, and stimulant properties. It acts as an antitussive and has antihyperalgesic effects. Patients should be advised that dextromethorphan hydrobromide and quinidine sulfate capsules may cause dizziness.
Is dextromethorphan safe?
- Talk to your provider or a pharmacist if you’re looking for a non-drowsy cough or cold medicine.
- Consideration should be given to initiating treatment with a lower dose of paroxetine if given with dextromethorphan hydrobromide and quinidine sulfate.
- In rare cases, dextromethorphan may cause serious side effects, including a severe allergic reaction.
- Dextromethorphan hydrobromide and quinidine sulfate capsules are available for oral use, which contains 20 mg dextromethorphan hydrobromide, USP and 10 mg quinidine sulfate, USP.
- Dextromethorphan should be stored at room temperature, between 68 F to 77 F (20 C to 25 C).
Inactive ingredients in the capsule are colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate and microcrystalline cellulose. The black imprinting ink contains ammonia solution, iron oxide black, potassium hydroxide, propylene glycol, and shellac. During development of dextromethorphan hydrobromide and quinidine sulfate, dose combinations of dextromethorphan/quinidine containing up to 6-times higher dextromethorphan dose and 12-times higher quinidine dose were studied. The most common adverse events were mild to moderate nausea, dizziness, and headache. Dose adjustment of dextromethorphan hydrobromide and quinidine sulfate is not required in patients with mild to moderate hepatic impairment.
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- For chronic respiratory conditions, alternative treatments are advised.
- Seek emergency medical attention if you think you have used too much of this medicine.
- Keep a list of all the medications you are using and check with your health care professional or doctor for additional medical advice if you need any further information.
- While serum quinidine levels can be measured, electrocardiographic monitoring of the QTc interval is a better predictor of quinidine-induced arrhythmia.
- DEXTROMETHORPHAN (dex troe meth OR fan) is used to relieve cough.
- There are no known interactions between dextromethorphan and foods or drinks.
Dextromethorphan is not addictive but has potential for abuse. Consult your doctor before taking dextromethorphan if pregnant or breastfeeding. Dextromethorphan is generally considered safe for children when used as directed.
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If you notice or experience signs of an allergic reaction like trouble breathing, hives, or swelling on the face, tongue, throat, or lips, seek medical help as soon as possible. It is not known if dextromethorphan passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Dextromethorphan may also be used for other conditions as determined by your healthcare provider. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Benzonatate is a non-narcotic cough medicine used to relieve coughing.
More about dextromethorphan / quinidine
It’s advisable to assess your response to the medication before engaging in activities that require alertness, and if drowsiness occurs, it’s recommended to avoid driving or operating heavy machinery. While Dextromethorphan is valuable for short-term relief from acute respiratory conditions, it is not typically recommended for managing long-term breathing issues such as emphysema or chronic bronchitis. These chronic conditions require a more comprehensive approach, often involving medications tailored to the specific nature of the respiratory ailment and long-term management strategies. It’s crucial for individuals with chronic respiratory conditions to consult healthcare professionals for personalized advice on managing their symptoms effectively and maintaining respiratory health over the long term. Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. Dextromethorphan is contained in many combination medicines available over the counter.
Read on to learn about potential common, mild, and serious side effects of dextromethorphan. For a general overview of the drug, including details about its uses, see this article. Advise patients to contact their healthcare provider if their PBA symptoms persist or worsen. Two additional studies conducted using a higher dose combination of dextromethorphan/quinidine (dextromethorphan 30 mg/quinidine 30 mg) provided supportive evidence of dextromethorphan hydrobromide and quinidine sulfate efficacy. Dextromethorphan hydrobromide and quinidine sulfate may be taken without regard to meals as food does not affect the exposure of dextromethorphan and quinidine significantly. Concomitant administration of quinidine with digoxin, a P-glycoprotein substrate, results in serum digoxin levels that may be as much as doubled.
Dextromethorphan may cause allergic reactions, which can be serious. Stop taking dextromethorphan and get help right away if you have any of the following symptoms of a serious allergic reaction. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
Dextromethorphan is metabolized by CYP2D6 and quinidine is metabolized by CYP3A4. After dextromethorphan 30 mg/quinidine 30 mg administration in extensive metabolizers, the elimination half-life of dextromethorphan was approximately 13 hours and the elimination half-life of quinidine was approximately 7 hours. Of the total number of patients with PBA in clinical studies of dextromethorphan hydrobromide and quinidine sulfate, 14 percent were 65 years old and over, while 2 percent were 75 and over. Clinical studies of dextromethorphan hydrobromide and quinidine sulfate did not include sufficient number of patients aged 65 and over to determine whether they respond differently than younger patients. It is not known whether dextromethorphan is excreted in human milk.