Dextromethorphan may cause allergic reactions, which can be serious. Stop taking dextromethorphan and get help right away if you have any of the following symptoms of a serious allergic reaction. Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.
They can tell you how much, if any, is safe to drink while taking dextromethorphan. Mild side effects of many drugs may go away within dextromethorphan cause drowsiness a few days to a couple of weeks. But if they become bothersome, talk with your doctor or pharmacist. Drowsiness is a possible side effect of dextromethorphan (an active ingredient in some Robitussin products).
- Studies were conducted with the individual components of dextromethorphan hydrobromide and quinidine sulfate in healthy subjects to determine single-dose and multiple-dose kinetics of orally administered dextromethorphan in combination with quinidine.
- Dextromethorphan oral capsule is approved for use in adults and children ages 12 years and older.
- But if you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away.
- A population pharmacokinetic analysis based on data from 109 subjects (75 male; 34 female) showed no apparent gender differences in the pharmacokinetics of dextromethorphan hydrobromide and quinidine sulfate.
- PND 7 in rat corresponds to the third trimester of gestation through the first several months of life but may extend to approximately three years of age in humans.
- Long-term misuse of dextromethorphan may lead to psychological dependence.
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Delsym is the brand-name medication that dextromethorphan suspension is based on. A generic is considered to be as safe and effective as the original drug. Some people misuse dextromethorphan by taking it in amounts higher than the recommended dosage to try to get high or hallucinate. People sometimes also misuse dextromethorphan by combining it with alcohol or other substances. Talk with your doctor or pharmacist if you have questions about drinking alcohol while taking dextromethorphan.
Healthcare professionals may recommend dextromethorphan for adults and some children. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs.
- If you take certain products together you may accidentally take too much of one or more types of medicine.
- Do not drive or do other activities that require alertness or coordination until you know how dextromethorphan affects you.
- But it cannot treat a cough that is caused by smoking, asthma, or emphysema.
- If in scope, these drugs will include RxNorm normal forms when editing is complete.
- The mean plasma C max of quinidine following twice daily co-administration of dextromethorphan 30 mg/quinidine 10 mg in patients with PBA was within 1 to 3% of the concentrations required for antiarrhythmic efficacy (2 to 5 mcg/mL).
- It’s not known whether dextromethorphan should be taken during pregnancy.
- To learn more, see “Overdose” in the “Dextromethorphan dosage” section above.
How Can I Stop My Child From Coughing?
It is part of the morphinan class of medications with sedative, dissociative, and stimulant properties. It acts as an antitussive and has antihyperalgesic effects. Patients should be advised that dextromethorphan hydrobromide and quinidine sulfate capsules may cause dizziness.
Keep out of reach of children
We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. If in scope, these drugs will include RxNorm normal forms when editing is complete. It’s not known whether dextromethorphan should be taken while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before taking this medication. It’s not known whether dextromethorphan should be taken during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before taking this medication.
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Talk with your doctor or pharmacist if you have drowsiness while taking dextromethorphan. Dextromethorphan comes as an oral liquid-filled capsule and an oral suspension. The mean plasma C max of quinidine following twice daily co-administration of dextromethorphan 30 mg/quinidine 10 mg in patients with PBA was within 1 to 3% of the concentrations required for antiarrhythmic efficacy (2 to 5 mcg/mL).
Drug Interactions
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Patients should not share or give dextromethorphan hydrobromide and quinidine sulfate capsules to others, even if they have the same symptoms, because they may harm them. The efficacy of dextromethorphan hydrobromide and quinidine sulfate was demonstrated in one trial in patients with pseudobulbar affect (PBA). These patients had underlying amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). Other trials at higher doses (dextromethorphan 30 mg/quinidine 30 mg) provided supportive evidence. In a two-year carcinogenicity study in rats, dextromethorphan/quinidine were administered at oral doses of 0/0, 5/100, 20/100, 50/100, 50/0, 0/100 mg/kg/day.
Evaluation and treatment of dextromethorphan hydrobromide and quinidine sulfate overdose is based on experience with the individual components, dextromethorphan and quinidine. This medicine will not be effective in curing cough caused by asthma, emphysema, or smoking. Its mechanism targets the central nervous system, making it suitable for symptomatic relief of acute cough due to common cold or respiratory infections. For chronic respiratory conditions, alternative treatments are advised.